IMAGE 1: A confocal image of a third instar Drosophila eye-antennal disc (green) in which transcription of the antennal and head capsule selector genes cut (red) and Lim1 (yellow) are restricted to the antennal disc via transcriptional repression by the retinal determination network. A set of migrating glial cells express cut and are seen entering the eye field through the optic stalk.
IMAGE 2: Light microscope image of a Drosophila eye-antennal disc. The forced expression of the transcription factor, sine oculis, induces the formation of an extra eye (green) within the antennal field indicating that it controls all of eye/lens development.
IMAGE 3: Light microscope image of a Drosophila eye-antennal disc. A disruption of the retinal determination network leads to the de-repression of non-retinal selector genes (green) and a homeotic transformation of the retina into head epidermis.Images courtesy of Justin Kumar lab